| Product name | Ethynyl estradiol |
| CAS NO | 57-63-6 |
| Purity | 85% |
| MF | C20H24O2 |
| MW | 296.4 |
| EINECS | 200-342-2 |
| Appearance | White Powder |
| Usage | Anti Estrogen Steroids |
| Synonyms |
NOVESTROL;NEO-ESTRONE;ETHYNYLESTRADIOL;ETHINYLE STRADIOL;LYNORAL;17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL;17ALPHA-ETHYNYLESTRADIOL;17ALPHA-ETHINYLESTRADIOL |
| Categories |
Alcohols-and-Derivatives;Steroids;Acetylenes;Biochemistry; Functionalized Acetylenes;Hydroxysteroids;Intermediates & Fine-Chemicals;Metabolites&Impurities;Pharmaceuticals;progestogen estrogen;ESTINYL;Hormone Drugs;Inhibitors |
Description
Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen . It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives .
Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later . It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme . Ethinyl Estradiol and its metabolites are excreted with the bile . Due to the effect of enterohepatic circulation a second peak is seen several hours later . Individually , wide variations exist in the overall absorption process , and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes . In circulation Ethinyl Estradiol is almost fully bound to plasma albumin . It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine , in part as glucuronide and sulfate conjugate .
Specification
| Product Name | Ethynyl Estradiol |
| Synonyms | Novestrol;Neo-Estrone;Ethynylestradiol;Ethinyl Estradiol;Lynoral;17alpha-Ethynyl-Delta1,3,5(10)-Estra-Triene-3,17beta-Diol;17alpha-Ethynylestradiol;17alpha-Ethinylestradiol |
| CAS | 57-63-6  |
| MF | C20H24O2 |
| MW | 296.4 |
| EINECS | 200-342-2 |
| Melting point | 182-183 °C(lit.) |
| Refractive index | -30 ° (C=0.4, Pyridine) |
| Solubility | ethanol: 50 mg/mL, clear, slightly yellow |
| Chemical Properties | Off-White to Light-Yellow Crystalline Powder |
| Air & Water Reactions | Air and light sensitive . Insoluble in water. |
| Reactivity Profile | Ethynyl estradiol may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to generate gaseous hydrogen. |
| Usage | A synthetic steroid. Used in combination with progestogen as an oral contraceptive. |
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