|Product name||Ethynyl estradiol|
|Usage||Anti Estrogen Steroids|
Functionalized Acetylenes;Hydroxysteroids;Intermediates & Fine-Chemicals;Metabolites&Impurities;Pharmaceuticals;progestogen estrogen;ESTINYL;Hormone Drugs;Inhibitors
Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen . It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives .
Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later . It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme . Ethinyl Estradiol and its metabolites are excreted with the bile . Due to the effect of enterohepatic circulation a second peak is seen several hours later . Individually , wide variations exist in the overall absorption process , and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes . In circulation Ethinyl Estradiol is almost fully bound to plasma albumin . It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine , in part as glucuronide and sulfate conjugate .
|Product Name||Ethynyl Estradiol|
|Melting point||182-183 °C(lit.)|
|Refractive index||-30 ° (C=0.4, Pyridine)|
|Solubility||ethanol: 50 mg/mL, clear, slightly yellow|
|Chemical Properties||Off-White to Light-Yellow Crystalline Powder|
|Air & Water Reactions||Air and light sensitive . Insoluble in water.|
|Reactivity Profile||Ethynyl estradiol may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to generate gaseous hydrogen.|
|Usage||A synthetic steroid. Used in combination with progestogen as an oral contraceptive.|