|Synonyms||Horny goat weed extract ; ICARIINE ; ICARRIN;epimedium extract ; Epimedium herb Ext ; Epimedium P.E ; Epimedium Brevicornum P.E ; Epimedim Brevicormum P.E|
|Chemical Properties||Light yellow to yellow solid|
|Usage||Male Sexual Enhancement|
Sex Steroid HormonesIcariin is a chemical compound classified as a flavonol glycoside , a type of flavonoid . It is the 8-prenyl derivative of kaempferol 3,7-O-diglucoside . The compound has been isolated from several species of plants belonging to the genus Epimedium which are commonly known as Horny Goat Weed or Yin Yang Huo . Extracts from these plants are reputed to produce aphrodisiac effects , and are used in traditional Chinese medicine to enhance erectile function .
Sex Steroid Hormones , It is thought that icariin is an active component of Epimedium extracts , as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence . In particular , icariin is a weak PDE5 inhibitor in vitro and enhances the production of nitric oxide , as well as mimicking the effects of testosterone in rats . It is a weak antioxidant and has antidepressant-like effects in mice . It also has neuroprotective effects in rats.
To effectively treat bone diseases using bone regenerative medicine , there is an urgent need to develop safe cheap drugs that can potently induce bone formation . Here , we demonstrate the osteogenic effect of icariin , the main active compound of Epimedium pubescens . Icariin induced osteogenic differentiation in pre-osteoblastic MC3T3-E1 cells and mouse primary osteoblasts . Icariin upregulated the mRNA expression levels of the osteoblast marker genes runt-related transcription factor 2 (Runx2) and inhibitor of DNA-binding 1 (Id-1) . The osteogenic effect was inhibited by the introduction of Smad6 or dominant-negative Runx2 , as well as Noggin treatment . Furthermore , icariin induced the mRNA expression of bone morphogenetic protein (BMP)-4 . These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression , production of BMP-4 and activation of BMP signaling . The extremely low cost of icariin and its high abundance make it appealing for bone regenerative medicine .
|Exterior||Light yellow to yellow solid||conform|
|Degree of fineness||100 mesh||conform|
|Loss on drying||＜5%||3.5%|
|Residue on ignition||＜2.5%||2.1%|
|Storage conditions||Top dry and low temperature sealing||Top dry and low temperature sealing|