| Product name | Icariin |
| Synonyms | Horny goat weed extract ; ICARIINE ; ICARRIN;epimedium extract ; Epimedium herb Ext ; Epimedium P.E ; Epimedium Brevicornum P.E ; Epimedim Brevicormum P.E |
| CAS | 489-32-7 |
| MF | C33H40O15 |
| MW | 676.66 |
| Chemical Properties | Light yellow to yellow solid |
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| Usage | Male Sexual Enhancement |
Description
Sex Steroid HormonesIcariin is a chemical compound classified as a flavonol glycoside , a type of flavonoid . It is the 8-prenyl derivative of kaempferol 3,7-O-diglucoside . The compound has been isolated from several species of plants belonging to the genus Epimedium which are commonly known as Horny Goat Weed or Yin Yang Huo . Extracts from these plants are reputed to produce aphrodisiac effects , and are used in traditional Chinese medicine to enhance erectile function .
Sex Steroid Hormones , It is thought that icariin is an active component of Epimedium extracts , as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence . In particular , icariin is a weak PDE5 inhibitor in vitro and enhances the production of nitric oxide , as well as mimicking the effects of testosterone in rats . It is a weak antioxidant and has antidepressant-like effects in mice . It also has neuroprotective effects in rats.
Application
To effectively treat bone diseases using bone regenerative medicine , there is an urgent need to develop safe cheap drugs that can potently induce bone formation . Here , we demonstrate the osteogenic effect of icariin , the main active compound of Epimedium pubescens . Icariin induced osteogenic differentiation in pre-osteoblastic MC3T3-E1 cells and mouse primary osteoblasts . Icariin upregulated the mRNA expression levels of the osteoblast marker genes runt-related transcription factor 2 (Runx2) and inhibitor of DNA-binding 1 (Id-1) . The osteogenic effect was inhibited by the introduction of Smad6 or dominant-negative Runx2 , as well as Noggin treatment . Furthermore , icariin induced the mRNA expression of bone morphogenetic protein (BMP)-4 . These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression , production of BMP-4 and activation of BMP signaling . The extremely low cost of icariin and its high abundance make it appealing for bone regenerative medicine .
Specification
| Exterior | Light yellow to yellow solid | conform | ||
| Degree of fineness | 100 mesh | conform | ||
| Loss on drying | ＜5% | 3.5% | ||
| Residue on ignition | ＜2.5% | 2.1% | ||
| Icariin | ＞10%(HPLC) | 12.9%(HPLC) | ||
| Distinguish | (+) | (+) | ||
| Heavy Metal | ＜5PPM | conform | ||
| bacterial | ＜1000cfu/g | 40cfu/g | ||
| Mold | ＜100cfu/g | ＜10cfu/g | ||
| E. coli | Negative | Negative | ||
| salmonella | Negative | Negative | ||
| Storage conditions | Top dry and low temperature sealing | Top dry and low temperature sealing | ||
| Conclusion | conform | |||
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