| Product name | Isotretinoin |
| Other Name | 13-cis-ra , 13-cis-retinoicaci , 13-ra , accutane , Isoretinoin , isotrex , neovitaminaacid , ro-4-3780. |
| Original | China |
| CAS | 4759-48-2 |
| ENIECS | 225-296-0 |
| Molecular formula | C20H28O2 |
| Leading time | within 24 hours upon receipt of payment |
| Delivery | Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS |
| Purity | 99.5% |
| Package | Discreet and Hidden package according to specific requirement |
| Appearance | Yellow Powder |
| Storage | −20°C |
| Certification | SGS, ISO 9001, KOSHER |
| Price | Negotiable |
| Usage | This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment |
| Molecular structure |  |
Description
Isotretinoin (INN), also known as 13-cis retinoic acid, is an oral pharmaceutical drug primarily used to treatsevere nodular acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.
Application
Isotretinoin belongs to the first generation of vitamin A acid. It is a stereoisomer of all-trans vitamin A acid. Oral administration has an anti-oil effect which has special effect on severe acne. The mechanism is as follows:
it can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment.
it has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands.
it can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity.
it can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses.
It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so isotretinoin can also suppress tumorigenesis.
when subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role.
Specification
COA:
| TEST ITEMS | SPECIFICATION | RESULTS |
| Description | Yellow Crystal Powder | Complies |
| Identification | The IR absorption spectrum should correspond |
Complies |
| Should exhibits maximum absorption at 354nm | Complies | |
| Assay | 98.0%-102.0% | 99.4% |
| Loss on drying | ≤0.5% | 0.07% |
| Tretinoin | ≤1.0% | 0.1% |
| Residue on ignition | ≤0.1% | 0.02% |
| Heavy metals | <0.002% | <0.002% |
| Conclusion | The specification conform with USP32 standard | |
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