Quick Details
| Product Name | sildenafil citrate |
| CAS No | 171599-83-0 |
| Synonyms | Sildenafil citrate; viagra |
| Assay | 98% |
| MF | C28H38N6O11S |
| MW | 666.7 |
| Appearance | Solid |
| Delivery time | within 3 work days upon receipt of payment |
| Shippment | EMS, DHL, TNT, FedEx, UPS |
| Usage | An orally active selective type 5 cGMP phosphodiesterase inhibitor Biological Activity :Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. |
| Melting point | 187-189°C |
Description
Sildenafil citrate was originally developed in 1991 as a treatment for angina, or chest pain. The drug, marketed under thename Viagra, received FDA market clearance as a treatment for impotence in March 1998, and since that time it hasbeen prescribed for over 10 million men worldwide. It was the first oral medication approved for ED treatment. A newerdrug, tadalafil, has been developed to treat men who do not respond to sildenafil. Tadalafil has gained preliminary approvalin the European Union (EU), and is in the final stages of regulatory approval in Canada as of November 2002.
Viagra is a vasodilator, a drug that has the effect of dilating the blood vessels. It works by improving blood circulation tothe penis, and by enhancing the effects of nitric oxide, the agent that relaxes the smooth muscle of the penis andregulates blood vessels during sexual stimulation, allowing the penis to become engorged and achieve an erection.
The average recommended dose of Viagra is 50 mg. For men that do not respond adequately to this amount, the dosagemay be increased up to 100 mg or decreased to 25 mg. The medication is taken approximately one hour before sexualactivity is planned, and may remain effective for up to four hours.
Viagra does not increase sexual desire. Sexual stimulation and arousal are required for the medication to be effective.Despite its widespread use as a recreational drug, it is not an aphrodisiac and there is no clinical evidence that itimproves sexual performance in men who are not suffering from ED.
Many insurance plans provide coverage or reimbursement for sildenafil citrate provided it is prescribed to treat erectiledysfunction. A 1999 report issued by a health insurance consulting group indicated that almost half of the men takingViagra at least once weekly receive insurance reimbursement for the drug. The pills cost approximately $10 each, andinsurers may limit coverage to a specific number of pills each month.
Applications:
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett.
The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.
In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, dyspepsia, nasal congestion and impaired vision, including photophobia and blurred vision.Some sildenafil users have complained of seeing everything tinted blue (cyanopsia).Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases and a number of studies have linked sildenafil use with nonarteritic anterior ischemic optic neuropathy.
Rare but serious adverse effects found through postmarketing surveillance include priapism, severe hypotension, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. As a result of these postmarketing reports, in October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss.
Specifications
| Product name | Sildenafil Citrate | |
| Appearance | White crystalline powder | |
| Loss on drying | ≤1.0% | 0.3% |
| Acidity | 3.0-5.0 | 4.1 |
| Residue on ignition | ≤0.1% | 0.05% |
| Heavy metals | ≤20ppm | Complies |
| Relevant impurity | ≤0.5% | 0.02% |
| Methanol | ≤0.3% | 0.025% |
| Methylene dichloride | ≤0.06% | 0.013% |
| N,N-Dimethyl formamide | ≤0.088% | Not detected |
| Assay(on dried basis) | ≥98% | 98.4% |
Our products are sold all over the world, you can rest assured.
