CAS 54-11-5 Pharmaceutical Raw Materials L Nicotine For Treat Smoking Withdrawal Syndrome

CAS No:54-11-5
Chemical Name: L-Nicotine
Synonyms: NO-FID;Emo-Nik;Nic-Sal;Tendust;Nicolan;Niconil;Tabazur;ent3,424;fluxmaag;Mach-Nic
Molecular Formula:C10H14N2

Formula Weight:162.23
Appearance: Pale yellow or yellow liquid

Melting point :-80 °C

Alpha :-166 º (c=neat)

Boiling point :243-248 °C

Density :1.010 g/mL at 20 °C(lit.)

refractive index :n20/D 1.5265(lit.)

Fp :215 °F

Storage:2-8°C

Solubility :ethanol: 50 mg/mL

pka:8.02(at 25℃)

Water Solubility :MISCIBLE

Sensitive :Air Sensitive & Hygroscopic.

Description

Nicotine is the substance in tobacco, nicotine content of tobacco because there are different species and origin, alkali content of tobacco each part is different. Cigarette factory scraps (tobacco powder) containing about 1% to 2% of the nicotine, tobacco stems and ribs smoke nicotine containing about 1% or so, people smoked cigarette contains nicotine amounted to about 3%. Pure nicotine is a colorless, oily liquid, miscible with water below 60 ℃, hydrate, more than 210 ℃ also miscible with water. Unstable nature, likely to be volatile, soluble in water and organic solvents. Nicotine is an alkaloid, so all properties of a base, to a compound made of salts and acids. In case of light and air turn brown and sticky, there is the odd smell and strong irritant.

Pure nicotine for people, livestock highly toxic rat oral LD50 of 50~60mg/kg, rabbit acute percutaneous LD5050mg/kg. Rabbit acute percutaneous LD50 for 50~60mg/kg, rabbit acute oral LD50 of 50mg/kg. Based on China's pesticide toxicity grading standards, is a highly toxic pesticides. However, because of volatile and rapidly decompose in air and light, and therefore can still be used to control pests on crops. Rapidly absorbed through the skin, inhalation and dermal exposure to toxic people. Toxic to birds. Young steelhead LC504mg/L, toxic to bees, but there insecticide effect. D. Pulex LC50 of 0.24mg/L. Fish and shellfish toxicity, mild injury to crops.

Liquids. Toxic by inhalation, ingestion, and skin absorption. More dense than water. Flash points usually below 140°F. Contact may irritate skin, eyes, and mucous membranes. 

Applications

(S)-(-)-Nicotine is a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.

Specification