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Home ProductsAnti Estrogen Steroids

Raw Steroid Powders Fulvestrant / Faslodex Astrazeneca CAS 129453-61-8 For Treat Cancer

Raw Steroid Powders Fulvestrant / Faslodex Astrazeneca CAS 129453-61-8 For Treat Cancer

Raw Steroid Powders Fulvestrant / Faslodex Astrazeneca CAS 129453-61-8 For Treat Cancer

Product Details:

Place of Origin: China
Brand Name: Rund
Certification: ISO9001
Model Number: CAS 129453-61-8

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: 10/100/250/500/1000g/foil bag
Delivery Time: 2-3 days
Payment Terms: T/T, Western Union, MoneyGram, BTCcoin
Supply Ability: 1000kg per momth
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Detailed Product Description
Product Name: Fulvestrant CAS: 129453-61-8
Appearance: White Powder MF: C32H47F5O3S
MW: 606.77 Assay: 97.0%~103.0%

Cancer Treatment Raw Steroid Powders Fulvestrant/Faslodex AstraZeneca CAS129453-61-8 White powder
 
Details

 

 

Product name:Fulvestrant

Alias:Faslodex AstraZeneca

CAS Registry Number:129453-61-8

Assay: 97.0%~103.0%

Molecular Fomular:C32H47F5O3S

Molecular Weight:606.77

Density:1.201 g/cm3

Melting Point:104-106℃

Appearance:white powder

Grade : Pharmaceutical Grade

Storage: Shading, confined preservation

Other drugs in same class:Anastrozole,Letrozole,Tamoxifen citrate,Exemestane

Usage:Fulvestrant is a type of hormone treatment. It is also called Faslodex. It is a treatment for post menopausal women with advanced breast cancer. A novel steroidal estrogen antagonist reported to lack any partial agonist activity. Also used as an antineoplastic raw materials.

 

Description

 

Product name Fulvestrant
Other name Faslodex AstraZeneca
CAS register number 129453-61-8
Molecular formula C32H47F5O3S
Molecular weight 606.77
Molecular structure Anti Estrogen Cutting Cycle Steroids Faslodex Hormonal Fulvestrant 129453-61-8
Assay 97.0%~103.0%
Appearance White powder
Package 1kg/aluminium foil bag or as required
Usage can be used as pharmaceutical material
Minimum order quantity 10g
Shipping By express courier
Shipping leading time Within 12 hours after receiving the payment
Payment options Western Union, MoneyGram, T/T
Price Negotiated

 

Application

 

Fulvestrant (Faslodex, AstraZeneca) is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works by down-regulating the estrogen receptor.

 

Fulvestrant is a selective estrogen receptor down-regulator (SERD). Fulvestrant is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. The dosing schedule for fulvestrant remains under investigation in an attempt to optimize its effectiveness.

 

Fulvestrant provided effective second-line therapy in this setting for postmenopausal women who had relapsed or progressed after previous endocrine therapy.

 

In particular 4 clinical trials in this setting did show similar efficacy to the other hormonal agents (aromatase inhibitors and tamoxifen) with good tolerability profile. Fulvestrant had a lower incidence of joint disorders.

 

Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cell has.

 

Specification

 

TEST ITEMS SPECIFICATION RESULTS
Appearance White to off-white powder White to off-white powder
Identification IR/HPLC Conforms
Specific Rotation +108°to +115° +110.9°
Water Not More Than 0.5% 0.3%
Sulphated Ash Not More Than 0.1% <0.1%
Heavy Metals Not More Than 20ppm <10ppm
Single impurity Not More Than 0.5% 0.15%
Total impurities Not More Than 1.0% 0.45%
FulvestrantA 42% ~48% 45%
Fulvestrant B 52% ~58% 55%
Assay(on anhydrous basis) 97.0% to 102.0% 98.9%
Toluene Not More Than 890ppm 200ppm
Ethyl acetate Not More Than 5000ppm 1300ppm
Conclusion The specification conform with enterprise standard.

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