Name:Dextromethorphan hydrobromide monohydrate (DXM)
Synonyms: dextromethorphansigmareference*standard;DMHM;D-Methorphan hydrobromide monohydrate
CAS: 6700-34-1
MF: C18H28BrNO2
MW: 370.32
Chemical Properties:White Solid
Packing:25kg/drum or as required
Usage: An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic).
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Chiral Reagents;Heterocycles.
Description
Dextromethorphan Hydrobromide is the hydrobromide salt form of dextromethorphan, a synthetic,
methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or
addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors
on the cough center in the central nervous system, thereby suppressing the cough reflex.
Application
Dextromethorphan Hydrobromide Monohydrate,Generic Dextromethorphan syrup.
Dextromethorphan Hydrobromide Monohydrate,The primary use of dextromethorphan is as a cough suppressant, for the temporary relief of cough,caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants.
In 2010, Dextromethorphan Hydrobromide Monohydrate,the FDA approved the combination product dextromethorphan/quinidine for the treatment of pseudobulbar affect (PBA).
Specification
COA:
| Test Items | Specification | Test Results |
| Appearance | white or almost white crystalline powder, slightly smelly | white crystalline powder |
| Melting point | 123~127 | 123~125 |
| Specific Rotation | +28~+30 | +29 |
| Acidity(PH) | 5.2~6.5 | 5.8~6.2 |
| Water | 4.0%~5.5% | 5.0% |
| Residue On Ignition | Not more than 0.1% | Conforms |
| N.N - dimethylaniline | Comply with the standard | Conforms |
| Phenolic Compounds | Comply with the standard | Conforms |
| Related Substance | Comply with the standard | Conforms |
| Assay | Between99.0~102.0% | 99.53% |
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