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154229-19-3 Pharmaceutical Intermediates Abiraterone Inhibitor C24H31NO 810-941-6

154229-19-3 Pharmaceutical Intermediates Abiraterone Inhibitor C24H31NO 810-941-6

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    154229-19-3 Pharmaceutical Intermediates

    ,

    Abiraterone Inhibitor Pharmaceutical Intermediates

    ,

    C24H31NO Pharmaceutical Intermediates

  • Product Name
    Abiraterone
  • Synonyms
    Abiraterone;Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)-;Cb 7598;Cb-7598;Unii-G819A456D0;Abiraterone(CB-7598);17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;CB-7598;CB7598;CB 7598
  • CAS
    154229-19-3
  • MF
    C24H31NO
  • MW
    349.52
  • EINECS
    810-941-6
  • Melting Point
    227-228 °C(Solv: Toluene (108-88-3))
  • Boiling Point
    500.2±50.0 °C(Predicted)
  • Density
    1.14±0.1 G/cm3(Predicted)
  • Purity
    99%
  • Place of Origin
    China
  • Brand Name
    RUN
  • Certification
    IOS9001
  • Model Number
    RUN-Z
  • Minimum Order Quantity
    10g
  • Price
    inquiry
  • Packaging Details
    10g 50g 100g 500g 1kg
  • Delivery Time
    3-7 days
  • Payment Terms
    T/T, MoneyGram, BTCcoin
  • Supply Ability
    1kg --100kg

154229-19-3 Pharmaceutical Intermediates Abiraterone Inhibitor C24H31NO 810-941-6

SECTION 1: Basic information

Abiraterone Basic information
description Therapeutic agent for prostate cancer How abiraterone works Mechanism of Action side effects Biological Activity
Product Name: Abiraterone
Synonyms: abiraterone;Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)-;Cb 7598;Cb-7598;Unii-G819A456D0;Abiraterone(CB-7598);17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;CB-7598;CB7598;CB 7598
CAS: 154229-19-3
MF: C24H31NO
MW: 349.52
EINECS: 810-941-6
Product Categories: Inhibitor;Inhibitors;API;Intermediates & Fine Chemicals;Steroids;Intermediate of Abiraterone Acetate;Pharmaceuticals
Mol File: 154229-19-3.mol
Abiraterone Structure
 
Abiraterone Chemical Properties
Melting point 227-228 °C(Solv: toluene (108-88-3))
Boiling point 500.2±50.0 °C(Predicted)
density 1.14±0.1 g/cm3(Predicted)
pka 14.71±0.70(Predicted)
CAS DataBase Reference 154229-19-3
 
 
Abiraterone Usage And Synthesis
description Abiraterone is a new type of hormone therapy. It is also called abiraterone acetate, CB7630 or Zytiga. It is used to treat prostate cancer that has spread to other parts of the body. It may help some men to live longer. It can also help control symptoms. Clinical trials are also using abiraterone for earlier stages of prostate cancer and advanced breast cancer. Abiraterone is associated with a not uncommon rate of serum enzyme elevation during therapy, but has not been clearly linked to cases of clinically apparent liver injury with jaundice.

On April 28, 2011, the U.S. Food and Drug Administration approved abiraterone acetate (Zytiga Tablets, Centocor Ortho Biotech, Inc.) for use in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) who have received prior chemotherapy containing docetaxel.

Abiraterone is a steroidal compound with antiandrogen activity. it is a Cytochrome P450 17A1 Inhibitor. The mechanism of action of abiraterone is as a Cytochrome P450 17A1 Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.

SECTION 2: Hazard identification

2.1 Classification of the substance or mixture

Reproductive toxicity, Category 2

Specific target organ toxicity – repeated exposure, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s) 154229-19-3 Pharmaceutical Intermediates Abiraterone Inhibitor C24H31NO 810-941-6 1
Signal word Warning
Hazard statement(s)

H361 Suspected of damaging fertility or the unborn child

H373 May cause damage to organs through prolonged or repeated exposure

Precautionary statement(s)
Prevention

P203 Obtain, read and follow all safety instructions before use.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

Response

P318 IF exposed or concerned, get medical advice.

P319 Get medical help if you feel unwell.

Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

2.3 Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Abiraterone Abiraterone 154229-19-3 - 100%

SECTION 4: First-aid measures

4.1 Description of necessary first-aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

SECTION 5: Fire-fighting measures

5.1 Suitable extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

6.2 Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2 Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available