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Healthly Raw Steroid Powders For Fighting Breast Cancer 107868-30-4 White powder Exemestane High purity 99%

Healthly Raw Steroid Powders For Fighting Breast Cancer 107868-30-4 White powder Exemestane High purity 99%

Healthly Raw Steroid Powders For Fighting Breast Cancer 107868-30-4 White powder Exemestane High purity 99%

Product Details:

Place of Origin: China
Brand Name: Rund
Certification: ISO9001
Model Number: CAS 107868-30-4

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: 10/100/250/500/1000g/foil bag
Delivery Time: 2-3 days
Payment Terms: T/T, Western Union, MoneyGram, BTCcoin
Supply Ability: 1000kg per momth
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Detailed Product Description
Product Name: Exemestane CAS: 107868-30-4
Appearance: White Crystalline Powder MF: C20H24O2
MW: 296.4 Assay(by HPLC): >98%

Healthly Raw Steroid Powders For Fighting Breast Cancer 107868-30-4 White powder Exemestane High purity 99%
 
Details

 

Product name: Exemestane

Alias: Aromasin ; Exemestan;Exemestane

Product Category: Pharmaceutical raw materials and intermediates

Assay: 98%min

CAS Registry Number:107868-30-4

Molecular formula: C20H24O2

Appearance: White or Almost White Crystalline Powder

Grade : Pharmaceutical Grade

Storage: Shading, confined preservation

Usage: Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds

Other drugs in same class: Anastrozole,Letrozole,Tamoxifen citrate,Exemestane

 

Description.

 

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.

The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.

 

Applications

 

Exemestane is an oral steroidal aromatase inhibitor that is used in ER-positive breast cancer in addition to surgery and/or radiation in post-menopausal women.

 

The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced via the conversion of androgens into estrogen by the aromatase enzyme in the peripheral tissues (i.e. adipose tissue like that of the breast) and a number of sites in the brain. Estrogen is produced locally via the actions of the aromatase enzyme in these peripheral tissues where it acts locally. Any circulating estrogen in post-menopausal women as well as men is the result of estrogen escaping local metabolism and entering the circulatory system.

 

Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, Exemestane permanently binds to the enzymes, preventing them from converting androgen into estrogen.

 

Exemestane is taken in tablet form once a day. Patients can experience side effects like nausea, anxiety, shortness of breath, abdominal pain, bone pain, and chest pain. Side effects vary widely between patients and patients should report the side effects they experience to their doctors, as some may be indicators of dangerous complications. Shortness of breath and chest pain in particular are causes for concern in patients taking exemestane.

 

Aromasin is used to fight breast cancer and raise testosterone in the body.

Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.

 

Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell. The different types of hormone therapies are categorized by their function and/or the type of hormone that is affected.

 

Specification

 

COA:

 

TEST ITEMS SPECIFICATION RESULTS
Description  White Crystalline Powder White Powder
Identification  Positive Positive
Assay(by HPLC)  98.0~102.0% 99.04%
Absorbance(E1cm)  465~495 482.5
Melting Point  191~195°C 193.5~195.0°C
Loss On Drying  0.5%max 0.19%
Specific Rotation  +288°~ +298° +290.2°
Residue On Ignition  0.1%max 0.03%
Related Substances  Total:1.5%max <1.3%
Single  0.5%max <0.4%
Residue Solvents  0.2%max 0.10%
Heavy Metals  20PPm max <10PPm
Conclusion The specification conform with enterprise standard.
 

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